LISTA DELLE PUBBLICAZIONI SU RIVISTE PEER REVIEWED

M. Falzoi , A. Mossa, E. Congeddu, L. Saba, L. Pani. Multiplex genotyping of CYP3A4, CYP3A5, CYP2C9 and CYP2C19 SNPs using MALDI-TOF mass spectrometry. Pharmacogenomics J. Provisionally scheduled to appear as a “Technology Report” on April 2010.

L. Luongo, E. Palazzo, S. Tambaro, C. Giordano, L. Gatta, M.A. Scafuro, F.sca Rossi, P. Lazzari, L. Pani, V. de Novellis, M. Malcangio, S. Maione. 1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c] pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice. Neurobiol Dis. (37): 177–185 2010.

D. Sanna, A. Sanna, L. Mara, S. Pilichi, A. Mastinu, F. Chessa, L.Pani, M. Dattena. Oct4 expression in in-vitro-produced sheep blastocysts and embryonic-stem-like cells. Cell. Biol. Int  2009

G Marchese, B Pittau, G Casu, G Peddio, GP Spada, M Pira, A Deriu, F Portesani, C Pisu, P Lazzari, L Pani. A comparison of continuous subcutaneous paliperidone infusion and repeated subcutaneous injection of risperidone free-base in rats. Eur Psychiatry. 2009

G. Marchese, G. Casu, P. Casti, GP. Spada, L Pani. Evaluation of amphetamine-induced hyperlocomotion and catalepsy following long-acting risperidone administration in rats. Eur J Pharmacol. 620(1-3):36-41 2009

F. Olimpieri, S. Tambaro, S. Fustero, P. Lazzari, M. Sanchez-Rosellò, L. Pani, A. Volonterio, M. Zanda. Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors. Bioorg Med Chem Lett,19(16):4715-9 2009

R. Sinisi, A. Ghilardi, S. Ruiu, P. Lazzari, L. Malpezzi, M. Sani, L. Pani, M. Zanda. Synthesis and in vitro evaluation of trifluoroethylamine analogues of enkephalines. ChemMedChem, 4(9):1416-20. 2009

L. Pani, G. Marchese. Expected clinical benefits of Paliperidone extended-release formulation when compared with Risperidone immediate-release. Expert Opin. Drug Del  (6)3: 319-331 2009

G. Marchese, A. Sanna, G. Casu, P. Casti, G. Pinna Spada , S. Ruiu, L. Pani. Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration. Eur J Pharmacol. 598(1-3):16-20. 2008

E. Sorisio, and S. Strøm (2008). Innovation and the Nordic erythropoiitin market, Rivista Internazionale di Scienze Sociali, 1: 99-126 2008

L. Pani, J.M. Villagran, V.P. Kontaxakis, K. Alptekin. Practical issues with amisulpride in the management of patients with schizophrenia. Clin Drug Investig. 28(8):465-77 2008.

R. Mongeau, M.A. Casu, L. Pani, G. Pillolla, L. Lianas, A. Giachetti. Building a virtual archive using brain architecture and Web 3D to deliver neuropsychopharmacology content over the Internet. Comput Methods Programs Biomed  90(2): 124-36 2008.

R. Mongeau, S. Marcello, J. Sparre Andersen, L. Pani. Contrasting effects of diazepam and repeated restraint stress on latent inhibition in mice. Behavioural Brain Research  183(2):147-55 2007.

L. Pani,  L. Pira,  G. Marchese. Antipsychotic efficacy: Relationship to optimal D2-receptor occupancy. Eur. Psychiatry 22(5):267-75 2007.

G. Loriga, S. Ruiu, I. Manca, G. Murineddu, C. Dessì, L. Pani, G.A Pinna.  3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]heptanes as novel potent dopamine uptake inhibitors. Bioorg. Med. Chem. 15(11):3748-55 2007.

M. A. Casu , A. Sanna, G. Pinna Spada, M. Falzoi, R. Mongeau , L. Pani. Effect of acute and chronic valproate treatments on p-CREB levels in the rat amygdala and nucleus accumbens. Brain Research 1141:15-24 2007.

M. Molteni, A. Volonterio, G. Fossati, P. Lazzari, L. Bruché, M. Zanda. Conjugated additions of amines and b-amino alcohols to trifluorocrotonic acid derivatives: synthesis of y[CH(CF3)NH]-retro-thiorphan. Tetrahedron Letters, 48 (4): 589-593 2007.

G. Murineddu, P. Lazzari, S. Ruiu, A. Sanna, G. Loriga, I. Manca, M. Falzoi, C. Dessì, M.M. Curzu, G. Chelucci, L. Pani, G.A. Pinna. Tricyclic pyrazoles. 4. Synthesis and Biological Evaluation of Analogues of the Robust and Selective CB2 Cannabinoid Ligand 1-(2’,4’-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. Journal of Medicinal Chemistry  49,(25):7502-7512 2006.

S. Tambaro, R. Mongeau, C. Dessì, L. Pani, S. Ruiu. Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors.  Eur.J.Pharmacol 525, (1-3):150-3 2005.

G. Murineddu, S. Ruiu, G. Loriga, I. Manca, P. Lazzari,  R. Reali, L.Pani, L. Toma and G. A. Pinna. Tricyclic pyrazoles. Part 3. Synthesis, biological evaluation and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2’,4’-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide (NESS 0327). Journal of Medicinal  Chemistry 48, (23):7351-7362 2005.

 M.A. Casu, C.Pisu, A. Sanna, S. Tambaro, G. Pinna Spada, R. Mongeau, L.Pani. Effect of Δ9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study. Brain Research 1048, (1-2):41-7 2005.

L.  Saba, A. Porcella, A. Sanna, E. Congeddu, N. Marziliano, R. Mongeau, D. Grayson, L. Pani. Five mutations in the GABAA α6 gene 5’ flanking region are associated with a reduced basal and ethanol-induced α6 upregulation in mutated Sardinian alcohol-non preferring rats. Mol Brain Res 137, (1-2): 252-257 2005.

F. Caboi, P. Lazzari, L. Pani, M. Monduzzi. Effect of 1-butanol on the microstructure of Lecithin/Water/Tripalmitin system". Chemistry and Physics of Lipids 135: 147-156 2005.

G. Murineddu, S Ruiu, JM Mussinu, G Loriga, GE Grella, MA Carai, P Lazzari, L Pani, GA Pinna. Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptors. Bioorg.Med.Chem. 13(9):3309-20 2005.

S. Tambaro, S. Ruiu, C. Dessi, R. Mongeau, G. Marchese, and L. Pani. Evaluation of tamsulosin and alfuzosin activity in the rat vas deferens: relevance to ejaculation delays. J.Pharmacol.Exp.Ther. 312(2):710-7 2005.

P. Casti, G. Marchese, G. Casu, S. Ruiu, and L. Pani. Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in mice. Neuropharmacology 47 (1):128-135, 2004.

M. A. Casu, C. Pisu, C. Lobina, and L. Pani. Immunocytochemical study of the forebrain serotonergic innervation in Sardinian alcohol-preferring rats. Psychopharmacology (Berl) 172 (3):341-351, 2004.

PL  Ferrarini, V Calderone, T Cavallini, C Manera, G Saccomanni, L Pani, S Ruiu, and GL Gessa. Synthesis and biological evaluation of 1,8-naphtyridin-4 (1H)-on-3-carboxamide derivates as new ligands of cannabinoid receptors. Bioorg.Med.Chem. 12 (8):1921-1933, 2004.

S. J. Keith, L. Pani, B. Nick, R. Emsley, L. San, M. Turner, R. Conley, P. Scully, P. S. Chue, and B. Lachaux. Practical application of pharmacotherapy with long-acting risperidone for patients with schizophrenia. Psychiatr.Serv. 55 (9):997-1005, 2004.

G. Marchese, F. Bartholini, M. A. Casu, S. Ruiu, P. Casti, E. Congeddu, S. Tambaro, and L. Pani. Haloperidol versus risperidone on rat "early onset" vacuous chewing. Behav.Brain Res. 149 (1):9-16, 2004.

G. Marchese, F. Bartholini, S. Ruiu, P. Casti, G. L. Casu, and L. Pani. Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidol. Eur.J.Pharmacol. 483 (1):65-69, 2004.

L. Pira, R. Mongeau, and L. Pani. The atypical antipsychotic quetiapine increases both noradrenaline and dopamine release in the rat prefrontal cortex. Eur.J.Pharmacol. 504 (1-2):61-64, 2004.

G. Racagni, P. L. Canonico, L. Ravizza, L. Pani, and M. Amore. Consensus on the use of substituted benzamides in psychiatric patients. Neuropsychobiology 50 (2):134-143, 2004.

A. Sanna, E. Congeddu, L. Saba, A. Porcella, G. Marchese, S. Ruiu, P. Casti, P. Saba, and L. Pani. The cerebellar GABAA alpha6 subunit is differentially modulated by chronic ethanol exposure in normal (R100R) and mutated (Q100Q) sNP rats. Brain Res. 998 (2):148-154, 2004.

G. Brunetti, S. Serra, G. Vacca, C. Lobina, T. Curreli, M. A. Carai, G. Colombo, and G. L. Gessa. Long-term exposure to a sweetened alcoholic solution does not alter genetic aversion to ethanol in Sardinian alcohol-nonpreferring (sNP) rats. Alcohol 30 (1):29-34, 2003.

G. Brunetti, S. Serra, G. Vacca, C. Lobina, P. Morazzoni, E. Bombardelli, G. Colombo, G. L. Gessa, and M. A. Carai. IDN 5082, a standardized extract of Salvia miltiorrhiza, delays acquisition of alcohol drinking behavior in rats. J.Ethnopharmacol. 85 (1):93-97, 2003.

M. P. Castelli, L. Ferraro, I. Mocci, F. Carta, M. A. Carai, T. Antonelli, S. Tanganelli, G. Cignarella, and G. L. Gessa. Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid. J.Neurochem. 87 (3):722-732, 2003.

M. A. Casu, A. Porcella, S. Ruiu, P. Saba, G. Marchese, M. A. Carai, R. Reali, G. L. Gessa, and L. Pani. Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract. Eur.J.Pharmacol. 459 (1):97-105, 2003.

E. Congeddu, L. Saba, A. Porcella, A. Sanna, G. Marchese, C. Lobina, G. L. Gessa, and L. Pani. Molecular characterization of new polymorphisms at the beta2, alpha1, gamma2 GABA(A) receptor subunit genes associated to a rat non preferring ethanol phenotype. Brain Res.Mol.Brain Res. 110 (2):289-297, 2003.

P. Devoto, G. Flore, G. Vacca, L. Pira, A. Arca, M. A. Casu, L. Pani, and G. L. Gessa. Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic. Psychopharmacology (Berl) 167 (1):79-84, 2003.

A. Koukopoulos, G. Sani, A. E. Koukopoulos, G. P. Minnai, P. Girardi, L. Pani, M. J. Albert, and D. Reginaldi. Duration and stability of the rapid-cycling course: a long-term personal follow-up of 109 patients. J.Affect.Disord. 73 (1-2):75-85, 2003.

G. Marchese, P. Casti, S. Ruiu, P. Saba, A. Sanna, G. Casu, and L. Pani. Haloperidol, but not clozapine, produces dramatic catalepsy in Delta9-THC-treated rats: possible clinical implications. Br.J.Pharmacol. 140 (3):520-526, 2003.

J. M. Mussinu, S. Ruiu, A. C. Mule, A. Pau, M. A. Carai, G. Loriga, G. Murineddu, and G. A. Pinna. Tricyclic pyrazoles. Part 1: synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for CB1and CB2 cannabinoid receptors. Bioorg.Med.Chem. 11 (2):251-263, 2003.

G. A. Pinna, G. Cignarella, S. Ruiu, G. Loriga, G. Murineddu, S. Villa, G. E. Grella, G. Cossu, and W. Fratta. Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3' allyl end and at the phenyl ring of the cinnamyl chain on mu-receptor affinity and opioid antinociception. Bioorg.Med.Chem. 11 (18):4015-4026, 2003.

S. Ruiu, G. A. Pinna, G. Marchese, J. M. Mussinu, P. Saba, S. Tambaro, P. Casti, R. Vargiu, and L. Pani. Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor. J.Pharmacol.Exp.Ther. 306 (1):363-370, 2003.

S. Ruiu, G. Marchese, P. L. Saba, R. Satta, G. Gessa, A. Vaccari, and L. Pani. In vitro evidence for the presence of [3H]-haloperidol uptake in rat brain. Br.J.Pharmacol. 138 (1):188-192, 2003.

A. Sanna, E. Congeddu, A. Porcella, L. Saba, M. Pistis, M. Peis, G. Marchese, S. Ruiu, C. Lobina, D. R. Grayson, G. L. Gessa, and L. Pani. Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP). Brain Res. 967 (1-2):98-105, 2003.

S. Serra, G. Brunetti, G. Vacca, C. Lobina, M. A. Carai, G. L. Gessa, and G. Colombo. Stable preference for high ethanol concentrations after ethanol deprivation in Sardinian alcohol-preferring (sP) rats. Alcohol 29 (2):101-108, 2003.

G. Vacca, G. Colombo, G. Brunetti, S. Melis, D. Molinari, S. Serra, R. Seghizzi, P. Morazzoni, E. Bombardelli, G. L. Gessa, and M. A. Carai. Reducing effect of Salvia miltiorrhiza extracts on alcohol intake: influence of vehicle. Phytother.Res. 17 (5):537-541, 2003.

G. Addolorato, F. Caputo, E. Capristo, M. Domenicali, M. Bernardi, L. Janiri, R. Agabio, G. Colombo, G. L. Gessa, and G. Gasbarrini. Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol 37 (5):504-508, 2002.

G. Addolorato, F. Caputo, E. Capristo, L. Janiri, M. Bernardi, R. Agabio, G. Colombo, G. L. Gessa, and G. Gasbarrini. Rapid suppression of alcohol withdrawal syndrome by baclofen. Am.J.Med. 112 (3):226-229, 2002.

M. L. Barbaccia, G. Colombo, D. Affricano, M. A. Carai, G. Vacca, S. Melis, R. H. Purdy, and G. L. Gessa. GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid. Neuropharmacology 42 (6):782-791, 2002.

G. Brunetti, M. A. Carai, C. Lobina, S. Melis, S. Serra, G. Vacca, G. L. Gessa, and G. Colombo. Differences in ethanol-induced conditioned taste aversion in Sardinian alcohol-preferring and Sardinian alcohol-nonpreferring rats. Alcohol 26 (3):167-172, 2002.

M. A. Carai, R. Agabio, C. Lobina, R. Reali, G. Vacca, G. Colombo, and G. L. Gessa. GABA(B)-receptor mediation of the inhibitory effect of gamma-hydroxybutyric acid on intestinal motility in mice. Life Sci. 70 (25):3059-3067, 2002.

M. A. Carai, G. Brunetti, C. Lobina, S. Serra, G. Vacca, G. Minardi, G. Colombo, and G. L. Gessa. Proconvulsive effect of the GABA(B) receptor antagonist, SCH 50911, in rats undergoing ethanol withdrawal syndrome. Eur.J.Pharmacol. 445 (3):195-199, 2002.

M. A. Carai, G. Colombo, R. Reali, S. Serra, I. Mocci, M. P. Castelli, G. Cignarella, and G. L. Gessa. Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid. Eur.J.Pharmacol. 441 (3):157-163, 2002.

M. P. Castelli, I. Mocci, M. Pistis, M. Peis, D. Berta, A. Gelain, G. L. Gessa, and G. Cignarella. Stereoselectivity of NCS-382 binding to gamma-hydroxybutyrate receptor in the rat brain. Eur.J.Pharmacol. 446 (1-3):1-5, 2002.

M. A. Casu, D. Dinucci, G. Colombo, G. L. Gessa, and L. Pani. Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats. Brain Res. 948 (1-2):192-202, 2002.

M. A. Casu, G. Colombo, G. L. Gessa, and L. Pani. Reduced TH-immunoreactive fibers in the limbic system of Sardinian alcohol-preferring rats. Brain Res. 924 (2):242-251, 2002.

G. Colombo, S. Serra, G. Brunetti, G. Atzori, M. Pani, G. Vacca, G. Addolorato, W. Froestl, M. A. Carai, and G. L. Gessa. The GABA(B) receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats. Alcohol Alcohol 37 (5):499-503, 2002.

G. Colombo, S. Serra, G. Brunetti, R. Gomez, S. Melis, G. Vacca, M. M. Carai, and L. Gessa. Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats. Psychopharmacology (Berl) 159 (2):181-187, 2002.

P. Devoto, G. Flore, L. Pira, M. Diana, and L. Gessa. Co-release of noradrenaline and dopamine in the prefrontal cortex after acute morphine and during morphine withdrawal. Psychopharmacology (Berl) 160 (2):220-224, 2002.

G. Marchese, S. Ruiu, P. Casti, F. Bartholini, P. Saba, G. L. Gessa, and L. Pani. Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect. Eur.J.Pharmacol. 447 (1):109-114, 2002.

G. Marchese, S. Ruiu, P. Casti, P. Saba, G. L. Gessa, and L. Pani. Effect of the amisulpride isomers on rat prolactinemia. Eur.J.Pharmacol. 448 (2-3):263-266, 2002.

G. Marchese, M. A. Casu, F. Bartholini, S. Ruiu, P. Saba, G. L. Gessa, and L. Pani. Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigro-striatal dopaminergic neurons directly related to "early onset" vacuous chewing. Eur.J.Neurosci. 15 (7):1187-1196, 2002.

Pani L. Clinical implications of dopamine research in schizophrenia. Anonymous. Anonymous.  Curr Med Res Opin 18 suppl 3:3-7, 2002.

L. Pani and G. L. Gessa. The substituted benzamides and their clinical potential on dysthymia and on the negative symptoms of schizophrenia. Mol.Psychiatry 7 (3):247-253, 2002.

G. A. Pinna, G. Cignarella, G. Loriga, G. Murineddu, J. M. Mussinu, S. Ruiu, P. Fadda, and W. Fratta. N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes as mu-opioid receptor agonists. Effects on mu-affinity of arylalkenyl chain modifications. Bioorg.Med.Chem. 10 (6):1929-1937, 2002.

M. Pistis, L. Ferraro, L. Pira, G. Flore, S. Tanganelli, G. L. Gessa, and P. Devoto. Delta(9)-tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis study. Brain Res. 948 (1-2):155-158, 2002.

A. Porcella, G. Marchese, M. A. Casu, A. Rocchitta, M. L. Lai, G. L. Gessa, and L. Pani. Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid. Eur.J.Endocrinol. 147 (2):255-261, 2002.
S. Serra, G. Colombo, S. Melis, G. Vacca, M. A. Carai, and G. L. Gessa. Gamma-hydroxybutyric acid versus alcohol preference in Sardinian alcohol-preferring rats. Alcohol Alcohol 37 (2):128-131, 2002.

S. Serra, G. Brunetti, M. Pani, G. Vacca, M. A. Carai, G. L. Gessa, and G. Colombo. Blockade by the cannabinoid CB(1) receptor antagonist, SR 141716, of alcohol deprivation effect in alcohol-preferring rats. Eur.J.Pharmacol. 443 (1-3):95-97, 2002.

G. Vacca, S. Serra, G. Brunetti, M. A. Carai, G. L. Gessa, and G. Colombo. Boosting effect of morphine on alcohol drinking is suppressed not only by naloxone but also by the cannabinoid CB1 receptor antagonist, SR 141716. Eur.J.Pharmacol. 445 (1-2):55-59, 2002.

G. Vacca, S. Serra, G. Brunetti, M. A. Carai, H. H. Samson, G. L. Gessa, and G. Colombo. Operant self-administration of ethanol in Sardinian alcohol-preferring rats. Alcohol Clin.Exp.Res. 26 (11):1678-1685, 2002.

R. Agabio, M. A. Carai, C. Lobina, M. Pani, R. Reali, G. Vacca, G. L. Gessa, and G. Colombo. Alcohol stimulates motor activity in selectively bred Sardinian alcohol-preferring (sP), but not in Sardinian alcohol-nonpreferring (sNP), rats. Alcohol 23 (2):123-126, 2001.

R. Agabio, G. Colombo, M. A. Carai, and Gessa GL. Novel pharmacotherapies and patents for alcohol abuse and alcoholism. Expert Opin Ther Patents 11:1497-1521, 2001.

M. A. Carai, G. Colombo, G. Brunetti, S. Melis, S. Serra, G. Vacca, S. Mastinu, A. M. Pistuddi, C. Solinas, G. Cignarella, G. Minardi, and G. L. Gessa. Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid. Eur.J.Pharmacol. 428 (3):315-321, 2001.

M. P. Castelli, I. Mocci, A. M. Sanna, G. L. Gessa, and L. Pani. (-)S amisulpride binds with high affinity to cloned dopamine D(3) and D(2) receptors. Eur.J.Pharmacol. 432 (2-3):143-147, 2001.

G. Colombo, S. Melis, G. Brunetti, S. Serra, G. Vacca, M. A. Carai, and G. L. Gessa. GABA(B) receptor inhibition causes locomotor stimulation in mice. Eur.J.Pharmacol. 433 (1):101-104, 2001.

G. Colombo, C. Lobina, R. Agabio, G. Brunetti, G. Diaz, M. Littera, S. Melis, M. Pani, R. Reali, S. Serra, G. Vacca, M. A. Carai, and G. L. Gessa. Selective breeding of two rat lines differing in sensitivity to GHB and baclofen. Brain Res. 902 (1):127-130, 2001.

P. Devoto, G. Flore, L. Pani, and G. L. Gessa. Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex. Mol.Psychiatry 6 (6):657-664, 2001.

C. Lobina, G. Colombo, G. Brunetti, G. Diaz, S. Melis, M. Pani, S. Serra, G. Vacca, G. L. Gessa, and M. A. Carai. Procedure of bidirectional selective outbreeding for production of two rat lines differing in sensitivity to the sedative/hypnotic effect of gamma-hydroxybutyric acid. Brain Res.Brain Res.Protoc. 8 (1):74-81, 2001.

A. Porcella, C. Maxia, G. L. Gessa, and L. Pani. The synthetic cannabinoid WIN55212-2 decreases the intraocular pressure in human glaucoma resistant to conventional therapies. Eur.J.Neurosci. 13 (2):409-412, 2001.

L. Saba, A. Porcella, E. Congeddu, G. Colombo, M. Peis, M. Pistis, G. L. Gessa, and L. Pani. The R100Q mutation of the GABA(A) alpha(6) receptor subunit may contribute to voluntary aversion to ethanol in the sNP rat line. Brain Res.Mol.Brain Res. 87 (2):263-270, 2001.

S. Serra, M. A. Carai, G. Brunetti, R. Gomez, S. Melis, G. Vacca, G. Colombo, and G. L. Gessa. The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats. Eur.J.Pharmacol. 430 (2-3):369-371, 2001.

R. Agabio, M. A. Carai, C. Lobina, M. Pani, R. Reali, G. Vacca, G. L. Gessa, and G. Colombo. Development of short-lasting alcohol deprivation effect in sardinian alcohol-preferring rats. Alcohol 21 (1):59-62, 2000.

R. Agabio, M. A. Carai, C. Lobina, M. Pani, R. Reali, I. Bourov, G. L. Gessa, and G. Colombo. Dissociation of ethanol and saccharin preference in sP and sNP rats. Alcohol Clin.Exp.Res. 24 (1):24-29, 2000.

M. P. Castelli, I. Mocci, X. Langlois, W. Gommerendagger, W. H. Luyten, J. E. Leysen, and G. L. Gessa. Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain. Brain Res.Mol.Brain Res. 78 (1-2):91-99, 2000.

G. Colombo, R. Agabio, M. A. Carai, C. Lobina, M. Pani, R. Reali, G. Vacca, and G. L. Gessa. Different sensitivity to ethanol in alcohol-preferring sP and -nonpreferring sNP rats. Alcohol Clin.Exp.Res. 24 (11):1603-1608, 2000.

G. Colombo, R. Agabio, M. A. Carai, C. Lobina, M. Pani, R. Reali, and G. L. Gessa. Characterization of the discriminative stimulus effects of gamma-hydroxybutyric acid as a means for unraveling the neurochemical basis of gamma-hydroxybutyric acid actions and its similarities to those of ethanol. Alcohol 20 (3):237-245, 2000.

G. Colombo, R. Agabio, M. A. Carai, C. Lobina, M. Pani, R. Reali, G. Addolorato, and G. L. Gessa. Ability of baclofen in reducing alcohol intake and withdrawal severity: I--Preclinical evidence. Alcohol Clin.Exp.Res. 24 (1):58-66, 2000.

G. Colombo and Gessa GL. Gamma-hydroxybutyric acid in alcohol preference, dependence and withdrawal. Addict biol 5:389-403, 2000.

G. L. Gessa, R. Agabio, M. A. Carai, C. Lobina, M. Pani, R. Reali, and G. Colombo. Mechanism of the antialcohol effect of gamma-hydroxybutyric acid. Alcohol 20 (3):271-276, 2000.

G. L. Gessa, P. Devoto, M. Diana, G. Flore, M. Melis, and M. Pistis. Dissociation of haloperidol, clozapine, and olanzapine effects on electrical activity of mesocortical dopamine neurons and dopamine release in the prefrontal cortex. Neuropsychopharmacology 22 (6):642-649, 2000.

F. Nava, G. Carta, and G. L. Gessa. Permissive role of dopamine D(2) receptors in the hypothermia induced by delta(9)-tetrahydrocannabinol in rats. Pharmacol.Biochem.Behav. 66 (1):183-187, 2000.

L. Pani. Is there an evolutionary mismatch between the normal physiology of the human dopaminergic system and current environmental conditions in industrialized countries? Mol.Psychiatry 5 (5):467-475, 2000.

A. Porcella, C. Maxia, G. L. Gessa, and L. Pani. The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. Eur.J.Neurosci. 12 (3):1123-1127, 2000.

S. Ruiu, G. Marchese, P. L. Saba, G. L. Gessa, and L. Pani. The 5-HT2 antagonist ritanserin blocks dopamine re-uptake in the rat frontal cortex. Mol.Psychiatry 5 (6):673-677, 2000.

G. Carta, G. L. Gessa, and F. Nava. Dopamine D(2) receptor antagonists prevent delta(9)-tetrahydrocannabinol-induced antinociception in rats. Eur.J.Pharmacol. 384 (2-3):153-156, 1999.